本篇代寫essay-金納米顆粒講述了替代使用金鹽或局部應用金顆粒的方法是“關節內”應用AuNPs。它減少滑膜促炎細胞因子，並滲透到細胞水平，導致較少的臨牀和x線不規則行爲，在齧齒動物模型膠原說服關節炎。已有研究表明，AuNPs可作爲選擇性藥物局部給藥的載體。關節內使用AuNPs還需要進一步瞭解滑膜區域的屏障-載體協同作用，其中還包括滑膜對納米顆粒的滲透性。本篇代寫essay文章由英國第一論文 Assignment First輔導網整理，供大家參考閱讀。
A replacement of the use of salts of gold or application of gold particles locally is the “intra-articular” application of AuNPs. It decreases synovial pro-inflammatory cytokines and infiltrates at cellular level resulting in less number of clinical and radiographic irregularities done in a rodent model of collagen persuaded arthritis. It has been observed that AuNPs can act as carrier for local drug delivery for selective drugs. Intra-articular uses of AuNPs will need further specific understanding of the barrier-carrier synergy at the synovial region which also includes synovium permeability to nanoparticles (Laben et al., 2013).
Techniques associated with tissues in ex-vivo environment are already well-established in a number of biomedical areas and is a significant step in the progress towards high class discoveries related to in-vivo applications and finally in the field of clinical practice. The main benefits of using such nanoparticles comprise of standardization and control of the environment in which the experiment is carried and at the same time maintaining the physiological response of the tissue to the treatment (Laben et al., 2013). The AuNP synovium response and membrane permeation at the synovium helps to use the technique and application of AuNP in the treatment of osteoarthritis. The study on ex-vivo tissue modelling technique can be used to evaluate the permeability of size-specific AuNPs at the synovium and helps to establish whether the permeability prototype changes in lipopolysaccharide (LPS) presence or in the presence of interleukin-1β (IL-1β), synovial provocative cascades activators. Also it has been hypothesized that the tissues exposed to AuNPs in the ex-vivo environment would also show a decrease of biomarkers associated with inflammation in comparison to tissues used as controls (Laben et al., 2013).
Though nanoparticles show complex activities in biological systems based on their size, composition, shape, chemistry and surface charge. On the basis of the strength of the scattered light the hydrometric dimension describes the size of a spherical particle in a fluid medium encircled by the solvation coating. It also provides information related to the agglomeration or stability which is not dependent on the surface charge and finally the nanoparticle’s relations with other fluid components i.e. proteins and ions. Hydrodynamic size determination of AuNPs in chambers of different fluid components it can be concluded that agglomerated particles can be seen in saline solution and this can be increased in the presence of LPS and with the use of 1 % solution of bovine serum albumin it can be decreased (Laben et al., 2013).
Different study results suggested that application of 5nm (size at the dry state) AuNPs at the intra-articular region leads to permeation of particles through the joint capsule thus assists in methodical bioavailability. Based on this piece of information and from some other studies it can be expected further that the gold nanoparticles depart from the cavity of the joints in a size needy manor either unaided or inside the cells and gathers in the reticulo-endothelial system. Therefore it can be stated here that AuNPs can be largely reserved with the environment of synovium a sign which is positive for the treatment of osteoarthritis (Laben et al., 2013).