Loneliness may well be portrayed as unpleasant psychological position that takes place whilst an individual senses that he /she is detached or does not fit in a social set or system in various consequential mode. Loneliness is a sentiment that is shown up by broke social relationships with peers. This might openly direct to feelings that smash up the sense of worth. An additional well-known psychological indication connected with loneliness is nervousness. Loneliness is linked to disjointing anxiety disorders that result subsequent to splitting vital relationship with individuals (Moustakas, 2011). In “Of Mice and Men”, nervousness of loneliness is displayed by George in response to Lennie’s remembrance of rabbits. George nervously reacts that “The hell with the rabbits. That’s all you ever can remember is them rabbits. O.K.! Now you listen and this time you got to remember so we don’t get in any trouble. You remember settin’ in that gutter on Howard Street and watchin’ that blackboard?” Understandably, George dislikes the loneliness and splitting the vital social relationships of Lennie and his nervousness or unpleasantness is evident when he rubbish the uncalled for over love for the rabbits. George understands the importance of social relationship and believes that in order to cope with loneliness is to strive and get associated with community and to make stronger existing relationships. George puts “I could get along so easy and so nice if I didn’t have you on my tail. I could live so easy and maybe have a girl.” Loneliness becomes an unpleasant mood in which an individual, as in the case of George, suffers a tough sense of meaninglessness and isolation resulting from too little echelons of social relationships and this makes the individual frustrated who does not behave normally. Though it is a personal experience, it is about detachment from society, and requires to vigilant individuals in separation and inspires her/him to look for social associations. This is what Lennie requires to do with George so that he comes out from the unpleasant and frustrated mood of loneliness.