We can notice the physical pain of loneliness in “Of Mice and Men”, in the case of Crooks. “For Crooks was a proud, aloof man. He kept his distance and demanded that other people keep theirs. His body was bent over to the left by his crooked spine, and his eyes lay deep in his head, and because of their depth seemed to glitter with intensity. His lean face was lined with deep black wrinkles, and he had thin, pain-tightened lips which were lighter than his face.” Loneliness and isolation is a known social problem for an individual, but it ultimately turn out to be physical or take the form of physical pain and may put detrimental effects on health, as in the case the case of Crooks. It is in this context that Cacioppo and Hawkley (2009) try to persuade us to believe that loneliness is not just being alone, as interventions to cut loneliness and its health consequences may well necessitate taking into consideration it’s attentional, positive, and memorial biases with that of its social and behavioral effects.