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Research philosophy怎么写:叶酸靶向的多功能纳米载体

神经胶质瘤被认为是一种致命的脑部恶性肿瘤,不能通过化学疗法成功治疗。因此,考虑到胶质瘤的临床重要性,开发各种技术以提供适当的治疗。在此基础上,在实验室制备了具有叶酸功能的多功能纳米载体,能够有效地将DOX和siRNA共同传递到大鼠C6胶质瘤细胞中。因此,本实验在表达叶酸受体细胞方面取得了很大的成功。

Research philosophy怎么写:叶酸靶向的多功能纳米载体

在此基础上,激活了C6细胞的抗凋亡反应,并通过分子生物学研究揭示了其作用机制。以动物为例进行的研究为表明抗凋亡BCL-2基因明显下调提供了一个合适的例子。Bax基因的显著上调导致caspase-3的活化。肿瘤组织的细胞凋亡也明显上调。因此,采用叶酸靶向联合给药方案可适当达到治疗效果。

Research philosophy怎么写:叶酸靶向的多功能纳米载体

The glioma is considered as a fatal malignancy in the brain which cannot be successfully treated with aid of chemotherapy. Thus, the development of various techniques is undertaken for the purpose of providing appropriate treatment for the glioma with considering the clinical importance. On the basis of this factor, the folate functioned multifunctional nanocarrier is created in the lab which is effective for the co-delivering the DOX and the siRNA into the rat C6 glioma cells. Therefore, the achievement of this experiment created a great success with expressing the folate receptor cells.

Research philosophy怎么写:叶酸靶向的多功能纳米载体

With the aid of this, the anti-apoptotic responses in the C6 cells were activated and were also revealed by the molecular biological investigations. The study undertaken in the case of the animals provided an appropriate example for the purpose of indicating a distinct down-regulation of anti-apoptotic BCL-2 gene. It also showed the outstanding up-regulation of Bax gene which resulted in activation of the caspase-3. The up-regulation is also remarkably seen in the cell apoptosis in the tumor tissues. Henceforth, the healing effect can be appropriately achieved with using folate-targeted co-delivery plan.