In the year 1954 the micro technology was invented. After this the engineers felt the need to understand the structure of the electronic chips that were used in various instruments. With the discovery of compatible tools there also arise the needs of developing a technology which is compatible in size but still can perform tasks of large machines. Again the invention of various sensors like fluid sensors, airbag sensors and pressure sensors created more necessity of the microelectronic chips. And thus from 1966 the era of microelectronic chips began. The first successful lab on chip was developed in the year 1975 and was used in a Gas Chromatography. It was designed by a Professor at Stanford University known as S.C. Terry (Srinivasan, 2004). But till this period not much people were taking interest in the lab on chip. The main research and development of lab on chip was begun in 1990’s especially in Europe where the chips were used in pumps and fluid treatment systems. The lab on chip showed that the in the Fluid treatment systems those procedures like cleaning and separation that were earlier being done at a lab scale, with the integration of the microelectronic chips can be done at the production scale. This reduced lot of time and efforts. Lab on chip became popular in 1990 when they were started being used in various biotechnologically interesting tools like for DNA Micro Arrays, Genomics Applications and Capillary electrophoresis. Another biggest development that was seen was when the military units like Defence Advanced Research Projects Agency started researching on the chip in order to use it for analysis of any kind of biological or chemical weapons those were used in wars (Paik, 2003). Today major industries like software, communications, defence etc functions on the applications of lab on chip and so more and more research are being carried out in this field.