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英国论文代写推荐:冷冻干燥替代临界分析

在这一章中,我们将分析和讨论在脱细胞皮肤生产过程中,用低温储罐代替冷冻干燥器的问题。用于生物医药产品的保存方法是冷冻干燥和冷冻(产品保存在-80度)(Gilbert, Sellaro和Badylak, 2006)。这两种方法都有昂贵的成本。然而,这些方法的优点是,它可以给一个长货架期(通常约2年)的生物医学产品(Mellor, 1978)。如果我们将上述保存设备替换为生物医学产品的4度低温储存,生产和储存成本将会比以前低很多,但是这会导致生物医学产品的货架期会变得更短(Van et al, 2004)。因此,我们必须在货架期和成本之间进行权衡,这是值得的。介绍了生物医药生产中采用低温贮藏代替冷冻干燥机的成本分析,但如果货架期过短,会造成浪费。因此,它会导致的问题将如何浪费成本增加货架寿命变得越来越短,当将浪费费用节省的成本多取代冻结干燥器,这意味着,当将总生产成本仍然是便宜的冷冻干燥过程是生产过程中随着保质期太短。

脱细胞皮肤产品在组织工程领域变得越来越有用和安全。将脱细胞的皮肤产品储存起来是必要的,这样就可以随时使用。冷冻干燥工艺通常用于保存这些产品,因为它使货架期延长,而冷冻干燥是一个缓慢和昂贵的过程。对该工艺的替代方案进行了严格的分析,以实现快速、廉价的低温存储。研究表明,虽然它使加工速度快,成本低,但它带来的货架寿命的急剧下降,导致浪费率增加;其中废弃物占总成本的比例超过冷冻干燥的成本。因此,有人认为冷冻干燥比低温贮藏更有效。


英国论文代写推荐 :冷冻干燥替代临界分析

In this chapter, the issue that using the hypothermal storage to replace the freeze dryer in the decellularized skin production process will be analyzed and discussed. The preserve methods are using for biomedical products are freeze drying and frozen (the product is preserved in -80 degree) (Gilbert, Sellaro and Badylak, 2006). Both of the methods have an expensive cost. However, these methods have the advantage that it can give a long shelf life (usually around 2 years) of the biomedical product (Mellor, 1978). If we replace the above preserve equipment by a 4-degree hypothermal storage for the biomedical product, the production and storage cost will be much less than before, however, it will lead the disadvantage that the shelf life of the biomedical product will become much shorter (Van et al, 2004). Therefore, we have to trade-off between the shelf life and the costs and it is worthwhile. The cost analysis for replacing the freeze dryer with hypothermal storage in biomedical production is introduced, however, if the shelf life is too short, the wastage will be incurred. Therefore, it leads to the question that how will the waste costs increase as the shelf life become shorter and shorter, and when will the waste costs incurred more than the cost saved due to replacing the freeze dryer, which means that when will the total production cost is still cheaper with a freeze drying process is included in the production process as the shelf life becomes too short.

Decellularized skin products are becoming certainly useful and safer in the field of tissue engineering. It is necessary to store the decellularized skin products, so they can be used whenever needed. Freeze drying process is usually used in preserving these products as it makes the shelf life prolonged, whereas it is observed that freeze drying is a slow and expensive process. A replacement of the process has been critically analyzed to achieve fast and cheaper storage that is hypothermal storage. It is examined that although it makes the process fast and cheaper, it brings drastic decline in shelf life which results in increased waste rate; where the total cost of the waste proportion exceeds the cost of freeze drying. Hence, it has been suggested that freeze drying is more effective than hypothermal storage.