Assignment First

英国硕士论文字数分配:介孔二氧化硅纳米颗粒

通过介孔二氧化硅纳米颗粒将DOX与sirna共给药或联合给药,提供给多药耐药癌细胞,以达到最小提前放电的目的。在克服非泵阻力的同时,有效地提高了化疗的效率,避免了外排泵阻力。在这个问题上,必须记住的是,癌细胞对多药耐药的增长会产生副作用,这些副作用被证明是化疗成功的重要障碍。

英国硕士论文字数分配:介孔二氧化硅纳米颗粒

临床医学家正试图制定有效的策略,以克服耐药性,并以最低限度的早产药物的排放针对特定的肿瘤。这种特殊的治疗策略在癌症的治疗过程中有着巨大的影响。多药耐药是一种耐药表型,癌细胞同时转化为耐药以进行药物的增殖。没有发现明显的结构相似性,也没有看到不同的分子靶点。多药耐药或MDR可分为两类:泵耐药和非泵耐药。导致泵阻力的原因是一些蛋白质,使膜结合三磷酸腺苷(ATP)。非泵浦电阻的关键机制是通过Bcl-2蛋白初始激活细胞抗凋亡防御。

英国硕士论文字数分配:介孔二氧化硅纳米颗粒

Co-delivery or combined administration of DOX along with siRNAs by mesoporous silica nanoparticles were provided into the multidrug-resistance cancer cells for the purpose of achieving the minimum premature discharge. It substantially improves the efficiency of chemotherapy with overcoming the nonpump resistance as well as avoiding the efflux pump resistance. In this matter, it must be remembered that growth of resistance regarding the multidrug in cancer cells generates the adverse effects that are shown to be the important obstacles for successful chemotherapy.

英国硕士论文字数分配:介孔二氧化硅纳米颗粒

The therapists are trying to develop effective strategies to overcome the drug resistance and to target the particular tumor with a minimum discharge of the premature drug. This particular strategy has an immense impact in the curing process of cancer. The multidrug resistance is a resistance phenotype where the cancer cells turn into resistance simultaneously to multiply the drugs. The apparent structural similarity is not identified as well as the diverse molecular targets are seen. The multidrug resistance or MDR can be segregated into two different classes: pump resistance and non-pump resistance. The causes of pump resistance are few proteins, which make membrane bound adenosine triphosphate (ATP). The key mechanism of non-pump resistance is indicated in the form of activating cellular anti-apoptotic defense initially by Bcl-2 protein.