Main hurdles of Xenotranplantaion: The main hurdle which prevents the xenotransplantation from success is the graft rejection. There are many different mechanisms exist which account for incompatibility of organs between species leading to graft rejection. This includes hyperacute Ab-mediated rejection, acute T-cell-mediated rejection, and additional physiological related barriers (Dooldeniy and Warrens, 2003, p. 11-117).
Xenotransplanation in New Zealand: In New Zeland xenotranplantaion is mainly being investigated for the cure of diabetes. Auckland Company Diatranz is involved in the research to use porcin pancreatic cells for treating type1 diabetes. The technology basically involves encapsulating pig pancreatic islet cells which prevents the interaction of the cells with host immune system. These cells when mature release insulin which overcomes the deficiency of insulin. In October 2008, the misnistry of health, New Zealand gave approval for a clinical trial of xenoplanataion of pig cells into human.
Ethical and social issue: Though the xenotranplanation gives hope to overcome worldwide shortage of donor organs; however it also raises many social and ethical issues. Some of the important ethical issues include include informed consent complexities for research subjects, as well as the selection of human subjects, rights of patients and medical staff and public education (as many companies may go ahead with experiments without public awareness)( Vanderpool, 1999, p. 422)
Conclusion: Xenotransplation poses challenges at all levels of thought and action. Initial researches have shown positive result. Though it can be proved a potential means of saving many people suffering from organ failure; however it is also debated for social and ethical issues. In addition it also raises question of animal welfare against human interest. At last the xenotranplantation also raises the question that to what extends we can compromise the live for sake of animal welfare.
主要的障碍xenotranplantaion：主要障碍防止移植成功移植排斥。有许多不同的机制存在帐户不相容性器官物种之间，导致移植排斥。这包括急性抗体介导排斥反应，急性排斥反应和T细胞介导的，更多的生理有关的障碍（dooldeniy、沃伦，2003，p . 11-117）。